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Acetyl Hexapeptide-8

A peptide studied for the appearance of expression lines around the eyes.

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Reading the name

The ingredient is one part of a product. The formula is the whole mixture. A number such as 29 or 1 identifies a name; it is not a strength or quality score.

Exact label name: Acetyl Hexapeptide-8

Type of support: Ingredient study

Editorial draft · Qualified scientific review pending.

What it is

A synthetic peptide investigated under the name Argireline. The study concerns a specific preparation, not every product listing this ingredient.

Why it is used

Studied as a cosmetic ingredient for reducing the appearance of eye-area lines.

What the evidence means

A four-week randomized placebo-controlled trial enrolled 60 Chinese participants (3:1 allocation) and reported improved eye-area wrinkle measures. The inspected abstract does not establish results for the retail serums here or long-term benefit. A 24-hour laboratory skin-penetration study is a different kind of evidence, not a clinical efficacy trial.

Precautions and possible reactions

The 2025 safety panel concluded safe cosmetic use up to 0.005%; above that, it found insufficient data to determine safety. This is not evidence of harm above that amount. The pure-peptide concentrations in these compared serums are not verified, so this assessment cannot certify either bottle. A commercial blend percentage is not automatically the pure-peptide percentage.

Cosmetics can cause irritation or allergic reactions. Check the full ingredient list and follow product directions.

What this means for your comparison

There is human research on a preparation of this ingredient. That is different from a direct test of this serum.

Sources checked . Ingredient information is separate from testing a finished serum.

Sources you can check

Multi-Peptide + Copper Peptides US product label The Ordinary · Manufacturer / supplier information · Accessed 2026-10-20
Wang et al. (2013): randomized study of Argireline and eye-area lines American Journal of Clinical Dermatology / PubMed · Research / ingredient reference · Accessed 2026-10-20
Acetyl Hexapeptide-8 Amide: cosmetic safety assessment (2025) Cosmetic Ingredient Review / International Journal of Toxicology · Research / ingredient reference · Accessed 2026-10-20
Allergens in cosmetics: reactions and consumer precautions US Food and Drug Administration · Public health guidance · Accessed 2026-10-19
In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation Cutaneous and Ocular Toxicology / PubMed · Research / ingredient reference · Accessed 2026-10-20

Found on these recorded labels